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Is depression in parents, grandparents linked to grandchildren's depression?

It is well known that having depressed parents increases children's risk of psychiatric disorders. There are no published studies of depression examining three generations with grandchildren in the age of risk for depression and with direct interviews of all family members. Myrna M. Weissman, Ph.D., of Columbia University and New York State Psychiatric Institute, New York, studied 251 grandchildren (average age 18) interviewed an average of two times and their biological parents, who were interviewed an average of nearly five times, and grandparents interviewed up to 30 years. When first comparing two generations, the study suggests grandchildren with depressed parents had twice the risk of MDD compared with nondepressed parents, as well as increased risk for disruptive disorder, substance dependence, suicidal ideation or gesture and poorer functioning. Comparing three generations, the authors report grandchildren with both a depressed parent and depressed grandparent had ...